Vaccines Immunopathology and Immunomodulation (V2I)

Vaccines Immunopathology and Immunomodulation (V2I)

The V2I team aims at developing immune intervention strategies for lung health in two challenging situations where large animal models offer major advantages for tackling veterinary and medical problems: respiratory viral infections in early life and lung transplantation. In particular we are investigating innate immune mechanisms underlying these respiratory pathologies, with a special interest for macrophages and dendritic cells. We are trying to unravel the physio-pathological mechanisms of the Respiratory Syncytial Virus infection in young calf and mice and we develop immunomodulatory strategies based on the manipulation of the primo-colonizing microbiota of the respiratory tract. We are establishing vaccine strategies in neonates against respiratory viral infections (protein and nucleic acid vaccines, targeting dendritic cells) and we are studying the immune mechanisms of the vaccine response specific to early life. We are investigating the innate responses involved in lung transplantation in the pig model as well as in human patients and we develop immunomodulatory approaches through preconditioning lung with ex vivo perfusion and targeting macrophages and dendritic cells.

bandeau mars 2021

Modification date : 23 November 2023 | Publication date : 25 February 2009 | Redactor : Isabelle Schwartz-Cornil / Céline Urien